Networks underlying paroxysmal fast activity and slow spike and wave in Lennox-Gastaut syndrome

N Pillay; JS Archer; RAB Badawy; DF Flanagan; SF Berkovic; G Jackson

Journal article

Networks underlying paroxysmal fast activity and slow spike and wave in Lennox-Gastaut syndrome

N Pillay, JS Archer, RAB Badawy, DF Flanagan, SF Berkovic, G Jackson

Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2013

DOI: 10.1212/WNL.0b013e3182a08f6a

Abstract

Objective: To use EEG-fMRI to determine which structures are critically involved in the generation of paroxysmal fast activity (PFA) and slow spike and wave (SSW) (1.5-2.5 Hz), the characteristic interictal discharges of Lennox-Gastaut syndrome (LGS). Methods: We studied 13 well-characterized patients with LGS using structural imaging and EEGfMRI at 3 tesla. Ten patients had cortical structural abnormalities. PFA and SSWwere considered as separate events in the fMRI analysis. Results: Simultaneous with fMRI, PFA was recorded in 6 patients and SSW in 9 (in 2, both were recorded). PFA events showed almost uniform increases in blood oxygen level-dependent (BOLD) signal in "association" cortical..

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University of Melbourne Researchers

John Archer Author

Sam Berkovic Author

Graeme Jackson Author

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Grants

Awarded by National Health and Medical Research Council of Australia

Awarded by NHMRC

Awarded by Academy of Finland (AKA)

Funding Acknowledgements

Supported by the National Health and Medical Research Council of Australia Program grant (628952) and an NHMRC practitioner fellowship to G.J. (527800), NHMRC Project grants 368650, 318900, 628725, and the Operational Infrastructure Support Program of the State Government of Victoria, Australia.